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Capillary gel electrophoresis 2

Glycoproteins 2

Hydrophilic interaction liquid chromatography 2

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N-glycans 2

Reversible labeling 2

N-glycans 1

N-glycosylation 1

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Diagnostic indicators 1

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans    

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Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Engineering doi: 10.1016/j.eng.2023.02.016

Abstract: As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent thatglycans’ immense complexity cannot be ignored.Through the detailed structural analysis of selected, dauntingly complex N-glycans from chicken ovalbuminMoreover, this approach “visualizes” N-glycans that have been difficult to identify thus far—such asthe sulfated glycans on human immunoglobulin A—including minute changes in glycan structures, potentially

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary gel    

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Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Engineering 2023, Volume 26, Issue 7,   Pages 17-31 doi: 10.1016/j.eng.2023.03.013

Abstract: Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycansalterations in protein glycosylation have been implicated in a growing number of human diseases, and glycans

Keywords： Glycome     Glycans     N-glycosylation     Genomics     Genetics     GWAS    

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Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches Article

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Engineering 2023, Volume 26, Issue 7,   Pages 132-150 doi: https://doi.org/10.1016/j.eng.2023.02.016

Abstract:

As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent thatglycans'  immense complexity cannot be ignored.Through the detailed structural analysis of selected, dauntingly complex N-glycans from chickenMoreover, this approach "visualizes" N-glycans that have been difficult to identifythus far—such as the sulfated glycans on human immunoglobulin A—including minute changes

Keywords： Glycoproteins     N-glycans     Reversible labeling     Hydrophilic interaction liquid chromatography     Capillary    

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Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid Article

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Engineering 2023, Volume 26, Issue 7,   Pages 119-131 doi: 10.1016/j.eng.2023.02.009

Abstract: report for the first time that Kdn is expressed on prostate-specific antigen (PSA) N-linked glycans

Keywords： Ketodeoxynononic acid     Kdn     Glycosylation     Prostate cancer     Prostate-specific antigen    

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Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Engineering 2023, Volume 26, Issue 7,   Pages 89-98 doi: 10.1016/j.eng.2023.01.006

Abstract: Here, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkers

Keywords： Systemic lupus erythematosus     N-glycans     Diagnostic indicators    

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Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: possible glycosites in the HCoV-19 spike protein (S protein), 20 are completely occupied by N-glycansangiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans

Keywords： N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Title Author Date Type Operation

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Journal Article

Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches

Samanta Cajic,René Hennig,Valerian Grote,Udo Reichl,Erdmann Rapp,

Journal Article

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Journal Article

Removable Dyes—The Missing Link for In-Depth N-Glycan Analysis via Multi-Method Approaches

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

Journal Article

Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Journal Article

Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus

Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu

Journal Article

Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article